PROGRAM

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MS-BASED UNTARGETED PROTEOMICS AND METABOLOMICS: CANCER METABOLISM, THERAPEUTIC TARGETS AND BIOMARKERS
MONDAY 1st JULY 2019:

Università degli Studi di Verona, aula magna “de Sandre”, Policlinico “G.B. Rossi”.

08:30 - 9:00 Registration
09:15 - 9:30 Opening Ceremony
09:30 - 10:15 “Using lipidomics analysis to identify therapeutic targets in cancer and infection”
Michael Wakelam (The Babraham Institute, Cambridge, UK)
10:15 - 10:30 “Advanced metabolomics workflows for accelerating the discovery of novel metabolic insights”
Anas Kamleh (Thermo Fisher)
10:30 - 11:00 Coffee Break & Posters
Chairs: Daniela Cecconi, Fulvio Magni
11:00 - 11:40 “Tumor suppressive function of lipolysis by proteomics and metabolomics”
Ruth Birner-Gruenberger (Omics Center Graz, Medical University of Graz, Austria)
11:40 - 12:00 “Fluxomics analisys to evaluate E3 Ubiquitin ligase MDM2 imbalance in the nucleotide metabolism in human breast cancer cell model”
Federica Gevi (Università della Tuscia)
12:00 - 12:20 “Characterization of Primary Aldosteronism by MS-based omics approaches”
Annalisa Castagna (Università di Verona)
12:20 - 12:35 "Differential protein and lipid regulation in breast cancer highlights changes for inflammatory, immunity and receptor signalling pathways”
David Heywood (Waters)
12:35 - 12:50 “A novel robust chromatography platform for deep and reproducible proteome coverage”
Christof Mitterer (PharmaFluidics)
12:50 - 14:00 Lunch Break & Posters
Chairs: Marcello Manfredi, Donatella Caruso
14:00 - 14:40 “Metabolomics within systems medicine, linking metabolism in the liver and the gut with the brain”
Cristina Legido-Quigley (King's College London)
14:40 - 15:10 “Stratification of patients based on the correlation between big data and clinic”
Andrea Petretto (IRCCS Istituto G. Gaslini, Genoa, Italy)
15:10 - 15:25 “Metabolomics screening in cancer patients: targeted and untargeted approaches”
Marialuce Maldini (AB SCIEX)
15:25 - 16:00 Coffee Break & Posters
Chairs: Massimo Donadelli, Daniela Cecconi
16:00 - 16:40 “Expression of lactate transporters (MCTs) in human cancers and exploitation as therapeutic targets”
Fátima Baltazar (University of Minho, Portugal)
16:40 - 17:10 “Warburg caught in a TRAP. The mitochondrial chaperone TRAP1 in neoplastic growth”
Andrea Rasola (University of Padua, Italy)
17:10 - 17:25 “Latest Hardware and Softwar e Innovations for Metabolomics”
Nicola Cimino (Agilent)
17:25 - 17:45 “Targeting SCF complex and protein turnover to overcome chemoresistance and trigger innate anti-tumour immune response in Malignant Pleural Mesothelioma”
Preeta Ananthanarayanan (Università di Torino)
17:45 - 17:55 Best poster awards
17:55 - 18:00 Closing remarks

ADVANCED SCHOOL "BIOINFORMATICS TOOLS FOR MASS SPECTROMETRY-BASED OMIC DATA: FROM PATHWAYS RECONSTRUCTION TO MULTI-OMIC DATA INTEGRATION”
TUESDAY 2nd JULY 2019:

Università degli Studi di Verona, aula Alpha, Dipartimento di Informatica

09:00 – 9:15 Welcome
09:15 - 9:45 Bioinformatics tools for in silico proteome and metabolome analysis (theory)
Marcello Manfredi (University of Eastern Piedmont)
09:45 - 11:00 Hands-on: MS spectra interpretation, database searching and processing
Daniela Cecconi (University of Verona, Dept. of Biotechnology)
11:00 - 11:45 Hands-on: proteomics data analysis (DAVID software), protein-protein interaction (String database)
Marcello Manfredi (University of Eastern Piedmont)
11:45 - 12:30 Hands-on: proteomics data pathway enrichment (Cytoscape), protein secretion (SecretomeP, SignalP, Vesiclepedia)
Jessica Brandi (University of Verona, Dept. of Biotechnology)
12:30 - 14:00 Lunch
14:00 - 14:45 Hands-on: metabolomics data analysis and pathway enrichment (MetaboAnalyst)
Marcello Manfredi (University of Eastern Piedmont)
14:45 - 16:00 Hands-on: multi-omics data integration by systems biology (Cytoscape)
Rosalba Giugno - Vincenzo Bonnici (University of Verona, Dept. of Computer Science)
16:00 - 16:30 Challenges and case studies
Daniela Cecconi - Jessica Brandi (University of Verona, Dept. of Biotechnology)
16:30 - 17:00 Summary - Wrap up - Discussions